Contactin 3 (CNTN3) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Contactin 3 (CNTN3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx100906
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Contactin 3 (CNTN3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Contactin 3 (CNTN3) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | PCS,PANG,BIG-1,KIAA1496,Plasmacytoma-associated neuronal glycoprotein,Brain-derived immunoglobulin superfamily protein 1,Contactin-3 |
| Background | Antibody anti-CNTN3 |
| Status | RUO |
Descripción
Contactin 3 (CNTN3), also known as BIG-1, is a neural adhesion molecule that belongs to the contactin family and is primarily expressed in the brain, particularly in areas involved in learning and memory, such as the hippocampus and cortex. CNTN3 mediates cell-cell adhesion and axonal interactions, contributing to synaptic formation and plasticity. It interacts with other neuronal receptors and adhesion molecules to regulate axon guidance and neuronal migration during development. CNTN3 has been implicated in neurodevelopmental disorders, including autism spectrum disorders and schizophrenia, where its dysregulation disrupts synaptic connectivity and neural circuit function. Its expression is developmentally regulated, with high levels observed during embryonic and early postnatal stages. Structurally, CNTN3 features immunoglobulin and fibronectin type III domains, facilitating homophilic and heterophilic interactions that are essential for its role in neural development. Emerging research suggests that CNTN3 may also have a role in neurodegenerative diseases and brain plasticity, though its exact mechanisms remain under investigation.
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