Mouse 5-Hydroxytryptamine Receptor 1D (HTR1D) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse 5-Hydroxytryptamine Receptor 1D (HTR1D) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx388472
tested applications
ELISA
Description
Mouse 5-Hydroxytryptamine Receptor 1D (HTR1D) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse HTR1D concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | 5-Hydroxytryptamine Receptor 1D (HTR1D) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 46.9 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q61224 |
| Gene ID | 15552 |
| Alias | HTR1D,HTRL,RDC4, HT1DA, 5-HT1D,,HTR1DA,5-HT1D receptor |
| Background | Elisa kits for HTR1D |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HTR1D is a member of the serotonin receptor family and is classified as a G protein-coupled receptor (GPCR) that mediates the inhibitory effects of serotonin (5-HT). Predominantly located in the central nervous system, particularly in regions like the trigeminal nerve and cerebral vasculature, HTR1D plays a crucial role in regulating vasoconstriction, pain modulation, and neurotransmitter release. It functions primarily as an autoreceptor, inhibiting serotonin release to maintain neurotransmitter balance. HTR1D has been strongly implicated in the pathophysiology of migraine headaches, where it mediates the constriction of intracranial blood vessels, reducing pain transmission. Triptan drugs, such as sumatriptan and zolmitriptan, act as selective HTR1D agonists and are widely used for the acute treatment of migraines by targeting this receptor to alleviate vasodilation and inflammation. Beyond migraines, HTR1D is also involved in modulating anxiety, mood, and nociception (pain perception). Dysregulation of this receptor can contribute to neuropsychiatric disorders such as depression and anxiety disorders. The study of HTR1D as a target for novel therapeutics offers opportunities for better migraine management and potential treatments for mood disorders through modulation of serotonin pathways.
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