5-Hydroxytryptamine Receptor 1D (HTR1D) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
5-Hydroxytryptamine Receptor 1D (HTR1D) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx030813
tested applications
ELISA, WB
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 5-Hydroxytryptamine Receptor 1D (HTR1D) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P28221 |
| Alias | HTR1D,HTRL,RDC4, HT1DA, 5-HT1D,,HTR1DA,5-HT1D receptor |
| Background | Antibody anti-HTR1D |
| Status | RUO |
Descripción
HTR1D is a member of the serotonin receptor family and is classified as a G protein-coupled receptor (GPCR) that mediates the inhibitory effects of serotonin (5-HT). Predominantly located in the central nervous system, particularly in regions like the trigeminal nerve and cerebral vasculature, HTR1D plays a crucial role in regulating vasoconstriction, pain modulation, and neurotransmitter release. It functions primarily as an autoreceptor, inhibiting serotonin release to maintain neurotransmitter balance. HTR1D has been strongly implicated in the pathophysiology of migraine headaches, where it mediates the constriction of intracranial blood vessels, reducing pain transmission. Triptan drugs, such as sumatriptan and zolmitriptan, act as selective HTR1D agonists and are widely used for the acute treatment of migraines by targeting this receptor to alleviate vasodilation and inflammation. Beyond migraines, HTR1D is also involved in modulating anxiety, mood, and nociception (pain perception). Dysregulation of this receptor can contribute to neuropsychiatric disorders such as depression and anxiety disorders. The study of HTR1D as a target for novel therapeutics offers opportunities for better migraine management and potential treatments for mood disorders through modulation of serotonin pathways.
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