Lysophosphatidic Acid Receptor 2 (LPAR2) Antibody
Pida mas información
935106861
info@markelab.com
Precio
187.5€ (50 µg)
Antibody anti-LPAR2
proveedor
Abbexareference
abx324102Tested Applications
ELISA, WB, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
LPAR2 Antibody is a Rabbit Polyclonal against LPAR2.
Background
LPAR2 is a G protein-coupled receptor for lysophosphatidic acid (LPA), expressed predominantly in epithelial tissues, the gastrointestinal tract, and immune cells. LPAR2 activation triggers signaling through Gq, Gi, and G12/13 proteins, leading to phospholipase C (PLC) activation, calcium mobilization, and Rho-mediated cytoskeletal changes. LPAR2 regulates cell proliferation, migration, and survival, playing important roles in tissue repair, immune responses, and cancer progression. In wound healing, LPAR2 promotes epithelial cell migration and proliferation, aiding tissue regeneration. In cancer, LPAR2 signaling enhances tumor cell survival, invasion, and resistance to apoptosis, particularly in ovarian and gastrointestinal cancers. LPAR2 also modulates immune responses by regulating cytokine production and immune cell migration. Dysregulation of LPAR2 is associated with inflammatory diseases and cancer metastasis. Targeting LPAR2 with selective antagonists is being explored for treating cancers and inflammatory conditions, as it contributes to pathological cell growth, migration, and survival.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Lysophosphatidic Acid Receptor 2 (LPAR2)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IF/ICC
purification
Purified by affinity chromatography.
buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
size 1
50 µg
size 2
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
LPAR2
dry ice
No
availability
Shipped within 5-10 working days.
alias
LPAR2,EDG4,LPA2,EDG-4,LPA-2,Pbx4,pre-B-cell leukemia transcription factor 4,endothelial differentiation gene 4,lysophosphatidic acid G-protein-coupled receptor 4
uniprot id
note
This product is for research use only.
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