Lysophosphatidic Acid Receptor 2 (LPAR2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Lysophosphatidic Acid Receptor 2 (LPAR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx212756
tested applications
ELISA, IHC
Description
LPAR2 Antibody is a Rabbit Polyclonal against LPAR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Lysophosphatidic Acid Receptor 2 (LPAR2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HBW0 |
| Gene ID | 9170 |
| Alias | LPAR2,EDG4,LPA2,EDG-4,LPA-2,Pbx4,pre-B-cell leukemia transcription factor 4,endothelial differentiation gene 4,lysophosphatidic acid G-protein-coupled receptor 4 |
| Background | Antibody anti-LPAR2 |
| Status | RUO |
Descripción
LPAR2 is a G protein-coupled receptor for lysophosphatidic acid (LPA), expressed predominantly in epithelial tissues, the gastrointestinal tract, and immune cells. LPAR2 activation triggers signaling through Gq, Gi, and G12/13 proteins, leading to phospholipase C (PLC) activation, calcium mobilization, and Rho-mediated cytoskeletal changes. LPAR2 regulates cell proliferation, migration, and survival, playing important roles in tissue repair, immune responses, and cancer progression. In wound healing, LPAR2 promotes epithelial cell migration and proliferation, aiding tissue regeneration. In cancer, LPAR2 signaling enhances tumor cell survival, invasion, and resistance to apoptosis, particularly in ovarian and gastrointestinal cancers. LPAR2 also modulates immune responses by regulating cytokine production and immune cell migration. Dysregulation of LPAR2 is associated with inflammatory diseases and cancer metastasis. Targeting LPAR2 with selective antagonists is being explored for treating cancers and inflammatory conditions, as it contributes to pathological cell growth, migration, and survival.
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