Leukotriene B4 Receptor 1 (LTB4R) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Leukotriene B4 Receptor 1 (LTB4R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234884
tested applications
ELISA, IHC
Description
LTB4R Antibody is a Rabbit Polyclonal against LTB4R.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leukotriene B4 Receptor 1 (LTB4R) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15722 |
| Alias | LTB4R,BLT1,BLTR,CMKRL1,GPR16,LTB4R1,LTBR1,P2RY7,P2Y7,BLTR,GPR16 |
| Background | Antibody anti-LTB4R |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
LTB4R, also known as BLT1, is a high-affinity G protein-coupled receptor for leukotriene B4 (LTB4), a potent lipid mediator derived from arachidonic acid. It is predominantly expressed on immune cells, such as neutrophils, monocytes, and T cells, where it regulates inflammatory responses and immune cell recruitment. Upon LTB4 binding, LTB4R activates downstream signaling pathways, including PI3K/Akt and MAPK, which promote chemotaxis, cytokine production, and reactive oxygen species (ROS) generation. LTB4R plays a critical role in acute and chronic inflammation, contributing to diseases such as asthma, rheumatoid arthritis, and inflammatory bowel disease (IBD). In cancer, LTB4R has been linked to tumor progression and metastasis by enhancing immune cell infiltration and angiogenesis within the tumor microenvironment. Dysregulated LTB4R signaling is also implicated in cardiovascular and metabolic disorders. Therapeutically, LTB4R antagonists are being developed to treat inflammatory and immune-mediated diseases by suppressing leukotriene B4-mediated responses, making it a key target for inflammation modulation.
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