Human Leukotriene B4 receptor 1 (LTB4R) ELISA Kit
513.5€ (96 tests)
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name
Human Leukotriene B4 receptor 1 (LTB4R) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx253537
tested applications
ELISA
Description
Human Leukotriene B4 receptor 1 (LTB4R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Leukotriene B4 receptor 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Leukotriene B4 receptor 1 (LTB4R) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Sensitivity | < 0.43 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q15722 |
| Alias | LTB4R,BLT1,BLTR,CMKRL1,GPR16,LTB4R1,LTBR1,P2RY7,P2Y7,BLTR,GPR16 |
| Background | Elisa kits for LTB4R |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LTB4R, also known as BLT1, is a high-affinity G protein-coupled receptor for leukotriene B4 (LTB4), a potent lipid mediator derived from arachidonic acid. It is predominantly expressed on immune cells, such as neutrophils, monocytes, and T cells, where it regulates inflammatory responses and immune cell recruitment. Upon LTB4 binding, LTB4R activates downstream signaling pathways, including PI3K/Akt and MAPK, which promote chemotaxis, cytokine production, and reactive oxygen species (ROS) generation. LTB4R plays a critical role in acute and chronic inflammation, contributing to diseases such as asthma, rheumatoid arthritis, and inflammatory bowel disease (IBD). In cancer, LTB4R has been linked to tumor progression and metastasis by enhancing immune cell infiltration and angiogenesis within the tumor microenvironment. Dysregulated LTB4R signaling is also implicated in cardiovascular and metabolic disorders. Therapeutically, LTB4R antagonists are being developed to treat inflammatory and immune-mediated diseases by suppressing leukotriene B4-mediated responses, making it a key target for inflammation modulation.
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