Leucine Rich Repeat In FLII Interacting Protein 1 (LRRFIP1) Antibody
169€ (20 µg)
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935106861
info@markelab.com
name
Leucine Rich Repeat In FLII Interacting Protein 1 (LRRFIP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx109966
tested applications
ELISA, IHC, IF/ICC
Description
Leucine-rich repeat flightless-interacting protein 1 Antibody is a Rabbit Polyclonal antibody against Leucine-rich repeat flightless-interacting protein 1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine Rich Repeat In FLII Interacting Protein 1 (LRRFIP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q32MZ4 |
| Gene ID | 9208 |
| NCBI Accession | NP_001131022.1, NM_001137550.1 |
| OMIM | 603256 |
| Alias | LRR FLII-interacting protein 1,GC-binding factor 2,GCF2, TRIP,GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1 |
| Background | Antibody anti-LRRFIP1 |
| Status | RUO |
Descripción
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) is a multifunctional protein implicated in various cellular processes, including transcriptional regulation, immune response modulation, and cytoskeletal organization. LRRFIP1 binds to transcription factors and regulates their activity, acting as a co-activator or repressor depending on the cellular context. Its role in innate immunity is highlighted by its interaction with the Toll-like receptor signaling pathway, where it influences the expression of pro-inflammatory cytokines such as IL-6 and TNF-alpha. Additionally, LRRFIP1 plays a role in actin cytoskeleton remodeling through its interaction with flightless I, a member of the gelsolin family. Dysregulation of LRRFIP1 expression or function has been associated with various pathological conditions, including cancer and autoimmune diseases. Studies have also identified its involvement in the Wnt signaling pathway, further emphasizing its significance in cellular proliferation and differentiation.
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