Human Leucine Rich Repeat In FLII Interacting Protein 1 (LRRFIP1) Protein
221€ (10 µg)
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name
Human Leucine Rich Repeat In FLII Interacting Protein 1 (LRRFIP1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067754
tested applications
WB, SDS-PAGE
Description
Recombinant Leucine Rich Repeat In FLII Interacting Protein 1 (LRRFIP1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Leucine Rich Repeat In FLII Interacting Protein 1 (LRRFIP1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 14.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu615-Asp735 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q32MZ4 |
| Alias | LRR FLII-interacting protein 1,GC-binding factor 2,GCF2, TRIP,GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1 |
| Background | Protein LRRFIP1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) is a multifunctional protein implicated in various cellular processes, including transcriptional regulation, immune response modulation, and cytoskeletal organization. LRRFIP1 binds to transcription factors and regulates their activity, acting as a co-activator or repressor depending on the cellular context. Its role in innate immunity is highlighted by its interaction with the Toll-like receptor signaling pathway, where it influences the expression of pro-inflammatory cytokines such as IL-6 and TNF-alpha. Additionally, LRRFIP1 plays a role in actin cytoskeleton remodeling through its interaction with flightless I, a member of the gelsolin family. Dysregulation of LRRFIP1 expression or function has been associated with various pathological conditions, including cancer and autoimmune diseases. Studies have also identified its involvement in the Wnt signaling pathway, further emphasizing its significance in cellular proliferation and differentiation.
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