Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025564
tested applications
ELISA, WB
Description
LRRC4B Antibody is a Rabbit Polyclonal antibody against LRRC4B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NT99 |
| Gene ID | 94030 |
| Alias | LRRC4B, LRIG4,Netrin-G3 ligand ,NGL-3 |
| Background | Antibody anti-LRRC4B |
| Status | RUO |
Descripción
LRRC4B, also known as netrin-G ligand 3 (NGL-3), is a transmembrane protein containing leucine-rich repeats that mediate synaptic adhesion, neuronal development, and signaling processes. It interacts with netrin-G proteins to form trans-synaptic connections that promote synapse formation, stabilization, and excitatory synaptic transmission in the central nervous system. LRRC4B is highly expressed in the brain, particularly in regions regulating learning, memory, and synaptic plasticity, where it supports the organization of neural circuits and dendritic spine maturation. Dysregulation of LRRC4B is associated with neurodevelopmental disorders, including autism spectrum disorders (ASD) and intellectual disabilities, due to impaired synaptic connectivity and function. Functional studies in knockout models demonstrate synaptic defects, abnormal neuronal morphology, and reduced synaptic transmission, emphasizing its essential role in maintaining excitatory synapse structure and function during brain development.
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