Leucine Rich Repeat Containing Protein 10 (LRRC10) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Leucine Rich Repeat Containing Protein 10 (LRRC10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234853
tested applications
ELISA, WB
Description
LRRC10 Antibody is a Rabbit Polyclonal against LRRC10.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine Rich Repeat Containing Protein 10 (LRRC10) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5BKY1 |
| Gene ID | 376132 |
| OMIM | 610846 |
| Alias | LRRC10 |
| Background | Antibody anti-LRRC10 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
LRRC10 is a heart-specific protein indispensable for proper cardiac development and contractile function. It acts as a cofactor in sarcomeric assembly, ensuring the structural organization of cardiac myofibrils, particularly at the Z-disc. LRRC10's deficiency has been linked to dilated cardiomyopathy (DCM), a condition characterized by ventricular enlargement and systolic dysfunction leading to heart failure. It also plays a role in mechanotransduction, influencing excitation-contraction coupling and calcium handling in cardiomyocytes. Studies involving LRRC10 knockout models reveal embryonic lethality or severe cardiomyopathy phenotypes, underscoring its importance in cardiogenesis. In adult models, LRRC10 dysfunction exacerbates cardiac remodeling under stress conditions, suggesting a protective role in cardiac adaptation. Furthermore, it may regulate sarcomeric protein phosphorylation, influencing contractility. Research is underway to explore its utility as a diagnostic marker or therapeutic target for heart failure, particularly in genetic forms of cardiomyopathy, as mutations in LRRC10 have been found in familial DCM cases, highlighting its clinical significance.
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