anti- LRRC10 antibody
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935106861
info@markelab.com
name
anti- LRRC10 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04853
tested applications
ELISA, WB
Description
May play important roles in cardiac development and/or cardiac function.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | leucine rich repeat containing 10 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 32 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q5BKY1 |
| Gene ID | 376132 |
| Alias | LRRC10 |
| Background | Antibody anti-LRRC10 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
LRRC10 is a heart-specific protein indispensable for proper cardiac development and contractile function. It acts as a cofactor in sarcomeric assembly, ensuring the structural organization of cardiac myofibrils, particularly at the Z-disc. LRRC10's deficiency has been linked to dilated cardiomyopathy (DCM), a condition characterized by ventricular enlargement and systolic dysfunction leading to heart failure. It also plays a role in mechanotransduction, influencing excitation-contraction coupling and calcium handling in cardiomyocytes. Studies involving LRRC10 knockout models reveal embryonic lethality or severe cardiomyopathy phenotypes, underscoring its importance in cardiogenesis. In adult models, LRRC10 dysfunction exacerbates cardiac remodeling under stress conditions, suggesting a protective role in cardiac adaptation. Furthermore, it may regulate sarcomeric protein phosphorylation, influencing contractility. Research is underway to explore its utility as a diagnostic marker or therapeutic target for heart failure, particularly in genetic forms of cardiomyopathy, as mutations in LRRC10 have been found in familial DCM cases, highlighting its clinical significance.
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