Human Leucine Rich Repeat Containing Protein 10 (LRRC10) ELISA Kit
715€ (96 tests)
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Leucine Rich Repeat Containing Protein 10 (LRRC10) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx388314
tested applications
ELISA
Descripción del producto
Human Leucine Rich Repeat Containing Protein 10 (LRRC10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human LRRC10 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| OMIM | 610846 |
| Alias | LRRC10 |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Background | Elisa kits for LRRC10 |
| Category | ELISA Kits |
| Detection Method | Colorimetric |
| Dry Ice | No |
| Form | Lyophilized |
| Gene ID | 376132 |
| Immunogen Target | Leucine Rich Repeat Containing Protein 10 (LRRC10) |
| Name | Human Leucine Rich Repeat Containing Protein 10 (LRRC10) ELISA Kit |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
| Price | 715 |
| Provider | Abbexa |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx388314 |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Sensitivity | < 0.094 ng/ml |
| Size 1 | 96 tests |
| Status | RUO |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Tested Applications | ELISA |
| UniProt ID | Q5BKY1 |
Descripcion del producto en español
Background en español
LRRC10 is a heart-specific protein indispensable for proper cardiac development and contractile function. It acts as a cofactor in sarcomeric assembly, ensuring the structural organization of cardiac myofibrils, particularly at the Z-disc. LRRC10's deficiency has been linked to dilated cardiomyopathy (DCM), a condition characterized by ventricular enlargement and systolic dysfunction leading to heart failure. It also plays a role in mechanotransduction, influencing excitation-contraction coupling and calcium handling in cardiomyocytes. Studies involving LRRC10 knockout models reveal embryonic lethality or severe cardiomyopathy phenotypes, underscoring its importance in cardiogenesis. In adult models, LRRC10 dysfunction exacerbates cardiac remodeling under stress conditions, suggesting a protective role in cardiac adaptation. Furthermore, it may regulate sarcomeric protein phosphorylation, influencing contractility. Research is underway to explore its utility as a diagnostic marker or therapeutic target for heart failure, particularly in genetic forms of cardiomyopathy, as mutations in LRRC10 have been found in familial DCM cases, highlighting its clinical significance.
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