Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) Antibody
357.5€ (100 µg)
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Name
Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx036605
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ISLR protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) Immunogen: Recombinant fragment corresponding to 111-275 AA of human ISLR. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 46 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Meflin,HsT17563 |
| Background | Antibody anti-ISLR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ISLR, also known as matrilin-4-related protein, is a secreted protein that belongs to the immunoglobulin superfamily and features leucine-rich repeat (LRR) domains. It is widely expressed in mesenchymal tissues, including those involved in the extracellular matrix (ECM) and connective tissue remodeling. ISLR plays a role in regulating cell adhesion, tissue repair, and fibroblast activation. ISLR is critical for maintaining the structural integrity of the ECM and facilitating tissue remodeling during processes such as wound healing and organ fibrosis. It interacts with integrins and other ECM components to modulate cellular signaling and promote mesenchymal cell differentiation. Dysregulation of ISLR has been implicated in fibrotic diseases, tumor progression, and metastasis, where it influences ECM dynamics and cell migration.
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