Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx128327
tested applications
WB, IHC, IF/ICC
Description
Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein Antibody is a Rabbit Polyclonal against Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14498 |
| Alias | Meflin,HsT17563 |
| Background | Antibody anti-ISLR |
| Status | RUO |
| Note | Concentration: 0.85 mg/ml - |
Descripción
ISLR, also known as matrilin-4-related protein, is a secreted protein that belongs to the immunoglobulin superfamily and features leucine-rich repeat (LRR) domains. It is widely expressed in mesenchymal tissues, including those involved in the extracellular matrix (ECM) and connective tissue remodeling. ISLR plays a role in regulating cell adhesion, tissue repair, and fibroblast activation. ISLR is critical for maintaining the structural integrity of the ECM and facilitating tissue remodeling during processes such as wound healing and organ fibrosis. It interacts with integrins and other ECM components to modulate cellular signaling and promote mesenchymal cell differentiation. Dysregulation of ISLR has been implicated in fibrotic diseases, tumor progression, and metastasis, where it influences ECM dynamics and cell migration.
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