Human SATB Homeobox Protein 1 (SATB1) Protein

Este producto es parte de SATB homeobox
Human SATB Homeobox Protein 1 (SATB1) Protein
208€ (10 µg)

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Name
Human SATB Homeobox Protein 1 (SATB1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx654989
Tested Applications
WB, SDS-PAGE

Description

Human SATB Homeobox Protein 1 (SATB1) Protein is a recombinant Human protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
SATB Homeobox Protein 1 (SATB1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Thr72-Gln445
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 45.7 kDa  Observed MW: 46 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
DEFDA,DHDBV,KTZSL,Special AT-Rich Sequence-Binding Protein 1,DNA-binding protein SATB1
Background
Protein SATB1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

SATB homeobox 1 (SATB1) is a global chromatin organizer and transcription factor that regulates gene expression by binding to specialized DNA sequences and anchoring chromatin loops to the nuclear matrix SATB1 plays a critical role in cellular differentiation, development, and lineage commitment, particularly in the immune system and during T-cell development It modulates chromatin accessibility and acts as a scaffold to recruit chromatin-modifying enzymes, thereby influencing gene activation and repression SATB1 is highly expressed in tissues undergoing rapid cellular growth and differentiation Dysregulation of SATB1 has been linked to cancer progression and metastasis, particularly in breast cancer, where it promotes oncogenic gene expression and cell invasion SATB1 also contributes to immune regulation, influencing T-cell function and immune responses Studies highlight its role in neurodevelopment and stem cell maintenance, where it regulates the expression of lineage-specific genes Its ability to coordinate large-scale chromatin remodeling makes SATB1 a critical regulator of gene expression, cellular identity, and disease pathogenesis across various biological contexts

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