Human SATB Homeobox Protein 1 (SATB1) Protein
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Description
Human SATB Homeobox Protein 1 (SATB1) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | SATB Homeobox Protein 1 (SATB1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 45.7 kDa Observed MW: 46 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr72-Gln445 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | DEFDA,DHDBV,KTZSL,Special AT-Rich Sequence-Binding Protein 1,DNA-binding protein SATB1 |
| Background | Protein SATB1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SATB homeobox 1 (SATB1) is a global chromatin organizer and transcription factor that regulates gene expression by binding to specialized DNA sequences and anchoring chromatin loops to the nuclear matrix SATB1 plays a critical role in cellular differentiation, development, and lineage commitment, particularly in the immune system and during T-cell development It modulates chromatin accessibility and acts as a scaffold to recruit chromatin-modifying enzymes, thereby influencing gene activation and repression SATB1 is highly expressed in tissues undergoing rapid cellular growth and differentiation Dysregulation of SATB1 has been linked to cancer progression and metastasis, particularly in breast cancer, where it promotes oncogenic gene expression and cell invasion SATB1 also contributes to immune regulation, influencing T-cell function and immune responses Studies highlight its role in neurodevelopment and stem cell maintenance, where it regulates the expression of lineage-specific genes Its ability to coordinate large-scale chromatin remodeling makes SATB1 a critical regulator of gene expression, cellular identity, and disease pathogenesis across various biological contexts
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