Human P2Y Purinoceptor 2 (P2RY2) ELISA Kit
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Description
Human Purinergic Receptor P2Y, G Protein Coupled 2 (P2RY2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Purinergic Receptor P2Y, G Protein Coupled 2 (P2RY2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | P2Y Purinoceptor 2 (P2RY2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 23.438 pg/ml - 1500 pg/ml |
| Sensitivity | < 14.1 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P41231 |
| Alias | P2RY2,ATP receptor,P2U purinoceptor 1,P2Y ATP receptor 2,P2Y purinoceptor 2,purinergic receptor P2Y,HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2 |
| Background | Elisa kits for P2RY2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
P2RY2 is a G protein-coupled receptor activated by ATP and UTP, serving as a key regulator of cellular responses to extracellular nucleotides. It is widely expressed in epithelial cells, endothelial cells, and immune cells, where it couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium, and modulating cytoskeletal dynamics and ion transport. P2RY2 plays a critical role in regulating inflammation, wound healing, and fluid secretion. In the respiratory tract, P2RY2 mediates mucus secretion and airway hydration, making it a therapeutic target for cystic fibrosis and chronic obstructive pulmonary disease (COPD). In addition, P2RY2 is involved in vascular remodeling, angiogenesis, and immune cell recruitment during tissue repair and inflammation. Dysregulation of P2RY2 contributes to inflammatory diseases, cardiovascular dysfunction, and fibrosis. P2RY2 agonists and antagonists are being explored for their potential in treating respiratory disorders, wound healing, and chronic inflammatory conditions.
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