Human Pro-Gastrin Releasing Peptide (ProGRP) Protein

Este producto es parte de GRP - Gastrin Releasing Peptide
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221€ (10 µg)

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935106861
info@markelab.com
name
Human Pro-Gastrin Releasing Peptide (ProGRP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168685
tested applications
WB, SDS-PAGE

Description

Human ProGRP Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Pro-Gastrin Releasing Peptide (ProGRP)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 14.0 kDa  Observed MW (SDS-PAGE): 16 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ser54-Gln148
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P07492
Alias
BN,GRP-10,proGRP,preproGRP
Background
Protein ProGRP
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Pro-Gastrin Releasing Peptide (ProGRP) is a precursor protein for gastrin-releasing peptide (GRP), a neuropeptide involved in a variety of physiological processes, including the regulation of gastric acid secretion, smooth muscle contraction, and pancreatic enzyme release. GRP is also known for its role in neural signaling, particularly in the central nervous system, where it modulates stress, memory, and circadian rhythm. ProGRP is a clinically significant biomarker, particularly in the diagnosis and monitoring of small cell lung cancer (SCLC), where elevated levels in serum are associated with disease presence and progression. The stability of ProGRP in circulation makes it a superior biomarker compared to GRP itself, as it provides a more reliable measure for diagnostic purposes. Beyond its use in oncology, ProGRP may play a role in gastrointestinal and neuroendocrine disorders, with its expression linked to cellular proliferation and secretion. Current research focuses on its potential as a therapeutic target in SCLC and other malignancies, as well as its broader role in neuroendocrine signaling pathways.

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