Human Pappalysin 2 (PAPPA2) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Pappalysin 2 (PAPPA2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx152637
tested applications
ELISA
Description
Human Pappalysin 2 (PAPPA2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Pappalysin 2 concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatant and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Pappalysin 2 (PAPPA2)
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Pappalysin 2 (PAPPA2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 31.2 ng/ml - 2000 ng/ml |
| Sensitivity | < 12.7 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatant and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | PLAC3,Pregnancy-associated plasma protein A2,PAPP-A2,Pregnancy-associated plasma protein E1,PAPP-E |
| Background | Elisa Kits for: PAPPA2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
PAPPA2, a close homolog of PAPPA, is also a zinc-dependent metalloproteinase that cleaves IGF-binding proteins, specifically IGFBP-5, to regulate the availability of insulin-like growth factors (IGFs). PAPPA2 is involved in controlling skeletal development, bone growth, and tissue regeneration by increasing IGF activity, which promotes cell proliferation and differentiation. It plays an essential role in fetal growth and development, with mutations in PAPPA2 linked to short stature and growth retardation due to reduced IGF bioavailability. PAPPA2 expression is also associated with metabolic disorders, such as insulin resistance and diabetes, and it has been implicated in certain cancers, where dysregulation of IGF signaling contributes to tumor progression. PAPPA2’s function in IGF regulation makes it a critical factor in growth-related processes and a potential target for therapeutic intervention.
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