Human Nucleoporin 188 kDa (NUP188) Protein

Name: Human Nucleoporin 188 kDa (NUP188) Protein
Brand: Abbexa
SKU: abx068359
Price: 247 EUR
Availability: OnlineOnly

Este producto es parte de NUP - nucleoporin

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein NUP188

proveedor

Abbexa

reference

abx068359

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Nucleoporin 188 kDa (NUP188) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Background

Nucleoporin 188 (NUP188) is an essential component of the nuclear pore complex (NPC), which regulates the selective transport of molecules between the nucleus and cytoplasm NUP188 participates in the structure and function of the nuclear pore, interacting with other nucleoporins to form the central channel that facilitates the movement of RNA, proteins, and other macromolecules across the nuclear envelope NUP188 plays a significant role in ensuring the proper nuclear-cytoplasmic exchange, which is critical for maintaining cellular processes such as gene expression, signal transduction, and cell cycle regulation Additionally, NUP188 is involved in the assembly and stability of the nuclear pore complex and may influence cell division and the response to DNA damage and oxidative stress Dysregulation of NUP188 has been associated with several diseases, including cancers, where defects in nucleocytoplasmic transport lead to uncontrolled cell growth and poor prognosis NUP188’s role in maintaining nuclear structure and regulating transport underscores its importance in cellular integrity and function

Características del producto

origin

Human

host

E. coli

immunogen target

Nucleoporin 188kDa (NUP188)

host

E. coli

conjugation

Unconjugated

form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

tested applications

WB, SDS-PAGE

size 1

10 µg

size 2

50 µg

size 3

100 µg

size 4

200 µg

size 5

500 µg

observerd MW

Molecular Weight: Calculated MW: 53.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr540-Gly782 Tag: N-terminal His tag and GST tag

expression

Recombinant

purity

> 95%

buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

or code

NUP188

dry ice

availability

Shipped within 5-12 working days.

alias

hNup188,KIAA0169,SANDSTEF,Nucleoporin NUP188

uniprot id

https://www.uniprot.org/uniprotkb/Q5SRE5

note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

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