Nucleoporin 188 kDa (NUP188) Antibody

Documentos del producto

Especificaciones del producto

Primary Antibodies

Target: Nucleoporin 188 kDa (NUP188)
Immunogen: NUP188 (Thr540-Gly782)

Rabbit

Human

WB (Predicted): 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

100 µl

200 µl

1 ml

Liquid

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

Shipped within 5-7 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

hNup188,KIAA0169,SANDSTEF,Nucleoporin NUP188

Antibody anti-NUP188

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Background

Nucleoporin 188 (NUP188) is an essential component of the nuclear pore complex (NPC), which regulates the selective transport of molecules between the nucleus and cytoplasm NUP188 participates in the structure and function of the nuclear pore, interacting with other nucleoporins to form the central channel that facilitates the movement of RNA, proteins, and other macromolecules across the nuclear envelope NUP188 plays a significant role in ensuring the proper nuclear-cytoplasmic exchange, which is critical for maintaining cellular processes such as gene expression, signal transduction, and cell cycle regulation Additionally, NUP188 is involved in the assembly and stability of the nuclear pore complex and may influence cell division and the response to DNA damage and oxidative stress Dysregulation of NUP188 has been associated with several diseases, including cancers, where defects in nucleocytoplasmic transport lead to uncontrolled cell growth and poor prognosis NUP188’s role in maintaining nuclear structure and regulating transport underscores its importance in cellular integrity and function