Human Neuromedin-B receptor (NMBR) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Neuromedin-B receptor (NMBR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx535412
tested applications
ELISA
Description
Human Neuromedin-B Receptor (NMBR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Neuromedin-B Receptor (NMBR) concentrations in tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Neuromedin-B Receptor (NMBR) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 23.0 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates, cell culture supernatant and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P28336 |
| Gene ID | 4829 |
| OMIM | 162341 |
| Alias | NMBR,BB1 receptor,NMB-R BB1,neuromedin B receptor,neuromedin-B-preferring bombesin receptor,BB1R,BRS1 |
| Background | Elisa kits for NMBR |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
The Neuromedin B receptor (NMBR) is a G-protein-coupled receptor (GPCR) that binds to neuromedin B (NMB), a peptide belonging to the bombesin-like peptide family. NMBR is widely expressed in the central nervous system (CNS), the gastrointestinal tract, and the lungs. In the CNS, NMBR plays a role in thermoregulation, particularly in body temperature control, by modulating hypothalamic pathways. It is also implicated in feeding behavior and satiety regulation, as it interacts with neuroendocrine circuits that suppress appetite. Beyond the CNS, NMBR influences smooth muscle contraction in the gastrointestinal tract, supporting motility and digestion processes. Its expression in the lungs contributes to pulmonary regulation, including bronchial smooth muscle contraction. Dysregulation of NMBR signaling has been linked to certain neurological disorders and cancer progression, especially in lung and prostate cancers, where it stimulates cell proliferation and migration. NMBR also modulates hormone secretion, including pituitary hormone release, further linking it to neuroendocrine functions. The receptor is currently being explored as a potential therapeutic target for disorders related to appetite regulation, obesity, and specific cancers, given its involvement in growth signaling pathways and cell division.
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