Human Lysophosphatidic Acid Receptor 2 (LPAR2) ELISA Kit

Este producto es parte de LPAR - Lysophosphatidic Acid Receptor
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Lysophosphatidic Acid Receptor 2 (LPAR2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx531251
tested applications
ELISA

Description

Human Lysophosphatidic Acid Receptor 2 (LPAR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Lysophosphatidic Acid Receptor 2 (LPAR2) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Lysophosphatidic Acid Receptor 2 (LPAR2)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9HBW0
Alias
LPAR2,EDG4,LPA2,EDG-4,LPA-2,Pbx4,pre-B-cell leukemia transcription factor 4,endothelial differentiation gene 4,lysophosphatidic acid G-protein-coupled receptor 4
Background
Elisa kits for LPAR2
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

LPAR2 is a G protein-coupled receptor for lysophosphatidic acid (LPA), expressed predominantly in epithelial tissues, the gastrointestinal tract, and immune cells. LPAR2 activation triggers signaling through Gq, Gi, and G12/13 proteins, leading to phospholipase C (PLC) activation, calcium mobilization, and Rho-mediated cytoskeletal changes. LPAR2 regulates cell proliferation, migration, and survival, playing important roles in tissue repair, immune responses, and cancer progression. In wound healing, LPAR2 promotes epithelial cell migration and proliferation, aiding tissue regeneration. In cancer, LPAR2 signaling enhances tumor cell survival, invasion, and resistance to apoptosis, particularly in ovarian and gastrointestinal cancers. LPAR2 also modulates immune responses by regulating cytokine production and immune cell migration. Dysregulation of LPAR2 is associated with inflammatory diseases and cancer metastasis. Targeting LPAR2 with selective antagonists is being explored for treating cancers and inflammatory conditions, as it contributes to pathological cell growth, migration, and survival.

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