Human Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) Protein

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
Product Graph
1872€ (1 mg)

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935106861
info@markelab.com
name
Human Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654170
tested applications
WB, SDS-PAGE

Description

Human Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) Protein is a Recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Leucine-Rich Repeat-Containing Protein 4B (LRRC4B)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
1 mg
Size 2
5 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 1-2 months.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9NT99
Gene ID
94030
Alias
LRRC4B, LRIG4,Netrin-G3 ligand ,NGL-3
Background
Protein LRRC4B
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

LRRC4B, also known as netrin-G ligand 3 (NGL-3), is a transmembrane protein containing leucine-rich repeats that mediate synaptic adhesion, neuronal development, and signaling processes. It interacts with netrin-G proteins to form trans-synaptic connections that promote synapse formation, stabilization, and excitatory synaptic transmission in the central nervous system. LRRC4B is highly expressed in the brain, particularly in regions regulating learning, memory, and synaptic plasticity, where it supports the organization of neural circuits and dendritic spine maturation. Dysregulation of LRRC4B is associated with neurodevelopmental disorders, including autism spectrum disorders (ASD) and intellectual disabilities, due to impaired synaptic connectivity and function. Functional studies in knockout models demonstrate synaptic defects, abnormal neuronal morphology, and reduced synaptic transmission, emphasizing its essential role in maintaining excitatory synapse structure and function during brain development.

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