Human Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) Protein
1872€ (1 mg)
1872€ (1 mg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654170
tested applications
WB, SDS-PAGE
Descripción del producto
Human Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | LRRC4B, LRIG4,Netrin-G3 ligand ,NGL-3 |
| Availability | Shipped within 1-2 months. |
| Background | Protein LRRC4B |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Category | Proteins and Peptides |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Expression | Recombinant |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Gene ID | 94030 |
| Host | E. coli |
| Immunogen Target | Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) |
| Name | Human Leucine-Rich Repeat-Containing Protein 4B (LRRC4B) Protein |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Origin | Human |
| Price | 1872 |
| Provider | Abbexa |
| Purity | > 90% |
| Reference | abx654170 |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Status | RUO |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Tested Applications | WB, SDS-PAGE |
| UniProt ID | Q9NT99 |
Descripcion del producto en español
Background en español
LRRC4B, also known as netrin-G ligand 3 (NGL-3), is a transmembrane protein containing leucine-rich repeats that mediate synaptic adhesion, neuronal development, and signaling processes. It interacts with netrin-G proteins to form trans-synaptic connections that promote synapse formation, stabilization, and excitatory synaptic transmission in the central nervous system. LRRC4B is highly expressed in the brain, particularly in regions regulating learning, memory, and synaptic plasticity, where it supports the organization of neural circuits and dendritic spine maturation. Dysregulation of LRRC4B is associated with neurodevelopmental disorders, including autism spectrum disorders (ASD) and intellectual disabilities, due to impaired synaptic connectivity and function. Functional studies in knockout models demonstrate synaptic defects, abnormal neuronal morphology, and reduced synaptic transmission, emphasizing its essential role in maintaining excitatory synapse structure and function during brain development.
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