Human Interferon Alpha 21 (IFNa21) Protein
247€ (10 µg)
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name
Human Interferon Alpha 21 (IFNa21) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067330
tested applications
WB, SDS-PAGE
Description
Human Interferon Alpha 21 (IFNa21) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interferon Alpha 21 (IFNa21) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 49.2 kDa Observed MW (SDS-PAGE): 50 kDa Concentration: Prior to lyophilization: 50 µg/ml Sequence Fragment: Asp25-Glu189 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration up to 0.25 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01568 |
| Alias | LeIF F,leIF-F,IFN-alphaI,IFN-alpha-21,Interferon alpha-F |
| Background | Protein IFNA21 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interferon Alpha 21 (IFNA21) is another crucial component of the type I interferon family, known for its role in innate and adaptive immunity. IFNA21 is rapidly upregulated in response to viral infections and pathogen-associated molecular patterns (PAMPs) recognized by Toll-like receptors and other sensors. It exerts its effects by binding to IFNAR, which activates downstream signaling pathways, including the JAK-STAT cascade, resulting in the induction of interferon-stimulated genes. These genes coordinate various antiviral mechanisms, such as inhibiting viral protein synthesis, degrading viral RNA, and upregulating major histocompatibility complex (MHC) molecules for enhanced antigen presentation. IFNA21 also plays a role in modulating the immune response by activating NK cells and promoting the differentiation and survival of cytotoxic T cells. Its functional specificity compared to other interferons, such as differences in potency or tissue-specific expression, underscores the complexity of the interferon system in orchestrating effective immune defenses against pathogens. Further investigations into IFNA21's unique properties could reveal novel therapeutic opportunities for infectious and immune-mediated diseases.
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