Human Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) Protein
234€ (10 µg)
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name
Human Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167981
tested applications
WB, SDS-PAGE
Description
Human Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Immunoglobulin Superfamily Containing Leucine Rich Repeat Protein (ISLR) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 47.6 kDa Observed MW (SDS-PAGE): 48 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys19-Phe428 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14498 |
| Alias | Meflin,HsT17563 |
| Background | Protein ISLR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ISLR, also known as matrilin-4-related protein, is a secreted protein that belongs to the immunoglobulin superfamily and features leucine-rich repeat (LRR) domains. It is widely expressed in mesenchymal tissues, including those involved in the extracellular matrix (ECM) and connective tissue remodeling. ISLR plays a role in regulating cell adhesion, tissue repair, and fibroblast activation. ISLR is critical for maintaining the structural integrity of the ECM and facilitating tissue remodeling during processes such as wound healing and organ fibrosis. It interacts with integrins and other ECM components to modulate cellular signaling and promote mesenchymal cell differentiation. Dysregulation of ISLR has been implicated in fibrotic diseases, tumor progression, and metastasis, where it influences ECM dynamics and cell migration.
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