Human Contactin 5 (CNTN5) Protein (Active)
975€ (50 µg)
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name
Human Contactin 5 (CNTN5) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692001
tested applications
SDS-PAGE
Description
Human Contactin 5 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the mature form of human CNTN5 (NP_055176.1) (Met 1-Gln 1059) with a C-terminal polyhistidine tag was expressed.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Contactin 5 |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Gln1059 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | 116 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_055176.1 |
| Alias | NB-2,HNB-2s,Neural recognition molecule NB-2,Contactin-5 |
| Background | Protein CNTN5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg as determined by the LAL method. |
Descripción
Contactin 5 (CNTN5), also known as NB-2, is a neural cell adhesion molecule that plays a significant role in synaptic organization, axon guidance, and neuronal communication. CNTN5 is primarily expressed in the central and peripheral nervous systems, particularly in sensory and auditory neurons, where it contributes to the formation of functional neural circuits. It mediates interactions with other adhesion molecules and receptors, influencing synaptic stability and plasticity. CNTN5 is linked to neurodevelopmental conditions, including autism and intellectual disability, as genetic variations affecting CNTN5 expression have been associated with altered brain connectivity and cognitive deficits. Its expression pattern is developmentally regulated, with high levels during embryonic stages that decrease postnatally. Structurally, CNTN5 shares the conserved immunoglobulin-like and fibronectin type III domains of the contactin family, enabling it to mediate diverse adhesive and signaling interactions crucial for nervous system function.
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