Contactin 5 (CNTN5) Antibody
52€ (10 µg)
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935106861
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name
Contactin 5 (CNTN5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx014395
tested applications
ELISA, IF/ICC
Description
Rabbit polyclonal antibody against CNTN5 protein. Immunogen region is C-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Contactin 5 (CNTN5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/100 - 1/500, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94779 |
| Alias | NB-2,HNB-2s,Neural recognition molecule NB-2,Contactin-5 |
| Background | Antibody anti-CNTN5 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Contactin 5 (CNTN5), also known as NB-2, is a neural cell adhesion molecule that plays a significant role in synaptic organization, axon guidance, and neuronal communication. CNTN5 is primarily expressed in the central and peripheral nervous systems, particularly in sensory and auditory neurons, where it contributes to the formation of functional neural circuits. It mediates interactions with other adhesion molecules and receptors, influencing synaptic stability and plasticity. CNTN5 is linked to neurodevelopmental conditions, including autism and intellectual disability, as genetic variations affecting CNTN5 expression have been associated with altered brain connectivity and cognitive deficits. Its expression pattern is developmentally regulated, with high levels during embryonic stages that decrease postnatally. Structurally, CNTN5 shares the conserved immunoglobulin-like and fibronectin type III domains of the contactin family, enabling it to mediate diverse adhesive and signaling interactions crucial for nervous system function.
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