Human Cleavage Stimulation Factor Subunit 3 (CSTF3) ELISA Kit

Background

Cleavage stimulation factor subunit 3 (CSTF3) is another essential element of the CstF complex, playing a vital role in 3' end cleavage and polyadenylation of pre-mRNAs, a process critical for mRNA maturation, stability, and export. CSTF3 functions as a homodimer and interacts with CSTF1 and CSTF2 to form the fully functional CstF complex, which participates in the recognition of cleavage sites on pre-mRNAs. It contains WD40 domains that facilitate protein-protein interactions, ensuring the stability and activity of the complex during the 3' end processing. CSTF3 is ubiquitously expressed across various tissues, highlighting its fundamental role in mRNA biogenesis. The CSTF3 gene undergoes alternative splicing, resulting in multiple transcript variants that encode different isoforms, potentially adapting its function to specific cellular contexts. CSTF3 not only participates in global mRNA processing but is also implicated in regulating alternative polyadenylation, which contributes to transcript diversity and gene expression regulation in response to developmental cues and external stimuli. Its broad expression and functional versatility emphasize its critical involvement in RNA metabolism.