Cleavage Stimulation Factor Subunit 3 (CSTF3) Antibody

Product specifications

Primary Antibodies

Cleavage Stimulation Factor Subunit 3 (CSTF3)

Rabbit

Human, Mouse, Rat

WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by affinity chromatography.

60 µl

120 µl

200 µl

Liquid

WB

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q12996

1479

NP_001028677.1

CSTF-77,CF-1 77 kDa subunit,Cleavage stimulation factor 77 kDa subunit

Antibody anti-CSTF3

RUO

Concentration: 1 mg/ml -

Descripción

Cleavage stimulation factor subunit 3 (CSTF3) is another essential element of the CstF complex, playing a vital role in 3' end cleavage and polyadenylation of pre-mRNAs, a process critical for mRNA maturation, stability, and export. CSTF3 functions as a homodimer and interacts with CSTF1 and CSTF2 to form the fully functional CstF complex, which participates in the recognition of cleavage sites on pre-mRNAs. It contains WD40 domains that facilitate protein-protein interactions, ensuring the stability and activity of the complex during the 3' end processing. CSTF3 is ubiquitously expressed across various tissues, highlighting its fundamental role in mRNA biogenesis. The CSTF3 gene undergoes alternative splicing, resulting in multiple transcript variants that encode different isoforms, potentially adapting its function to specific cellular contexts. CSTF3 not only participates in global mRNA processing but is also implicated in regulating alternative polyadenylation, which contributes to transcript diversity and gene expression regulation in response to developmental cues and external stimuli. Its broad expression and functional versatility emphasize its critical involvement in RNA metabolism.

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