Cleavage Stimulation Factor Subunit 3 (CSTF3) Antibody
377€ (100 µg)
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Name
Cleavage Stimulation Factor Subunit 3 (CSTF3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx232040
Tested Applications
ELISA, WB
Description
CSTF3 Antibody is a Rabbit Polyclonal against CSTF3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cleavage Stimulation Factor Subunit 3 (CSTF3) Immunogen: cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 77-83 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q12996 |
| Gene ID | 1479 |
| OMIM | 600367 |
| Alias | CSTF-77,CF-1 77 kDa subunit,Cleavage stimulation factor 77 kDa subunit |
| Background | Antibody anti-CSTF3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Cleavage stimulation factor subunit 3 (CSTF3) is another essential element of the CstF complex, playing a vital role in 3' end cleavage and polyadenylation of pre-mRNAs, a process critical for mRNA maturation, stability, and export. CSTF3 functions as a homodimer and interacts with CSTF1 and CSTF2 to form the fully functional CstF complex, which participates in the recognition of cleavage sites on pre-mRNAs. It contains WD40 domains that facilitate protein-protein interactions, ensuring the stability and activity of the complex during the 3' end processing. CSTF3 is ubiquitously expressed across various tissues, highlighting its fundamental role in mRNA biogenesis. The CSTF3 gene undergoes alternative splicing, resulting in multiple transcript variants that encode different isoforms, potentially adapting its function to specific cellular contexts. CSTF3 not only participates in global mRNA processing but is also implicated in regulating alternative polyadenylation, which contributes to transcript diversity and gene expression regulation in response to developmental cues and external stimuli. Its broad expression and functional versatility emphasize its critical involvement in RNA metabolism.
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