Human Chemokine C-X-C-Motif Receptor 5 (CXCR5) ELISA Kit

Product specifications

ELISA Kits

Chemokine C-X-C-Motif Receptor 5 (CXCR5)

Human

Colorimetric

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

< 0.06 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

CXCR5,BLR-1,MDR15,NLR,CD185,Burkitt lymphoma receptor 1,CXC-R5,Gpcr6,BLR1

Elisa kits for CXCR5

RUO

Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

CXCR5 is a G protein-coupled receptor expressed mainly on follicular B cells and T follicular helper (Tfh) cells, where it binds its ligand CXCL13. CXCR5 is critical for B cell homing to lymphoid follicles within secondary lymphoid organs, such as lymph nodes, spleen, and Peyer’s patches. It guides the migration of B cells and Tfh cells to germinal centers, facilitating antibody production, affinity maturation, and immune memory formation. CXCR5 signaling activates pathways like PI3K and ERK, driving cell migration and positioning within lymphoid tissues. In autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, dysregulated CXCR5 expression contributes to abnormal germinal center formation and autoantibody production. CXCR5 is also involved in chronic inflammatory diseases where it promotes immune cell accumulation. In cancer, CXCR5 expression is observed in B cell lymphomas and some solid tumors, where it enhances tumor growth, immune evasion, and metastasis. CXCL13-CXCR5 signaling in the tumor microenvironment supports lymphoid tissue-like structures that promote tumor progression. Therapeutically, targeting CXCR5 is being explored to modulate B cell activity in autoimmune diseases and lymphomas. CXCR5 is essential for coordinating B and Tfh cell migration, ensuring proper immune responses while contributing to disease pathology when dysregulated.

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