Chemokine C-X-C-Motif Receptor 5 (CXCR5) Antibody
221€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Chemokine C-X-C-Motif Receptor 5 (CXCR5) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx323492
Tested Applications
ELISA, WB
Description
CXCR5 Antibody is a Rabbit Polyclonal against CXCR5.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Chemokine C-X-C-Motif Receptor 5 (CXCR5) Immunogen: Synthesized peptide derived from the N-terminal region of human Blr1. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32302 |
| Gene ID | 643 |
| Alias | CXCR5,BLR-1,MDR15,NLR,CD185,Burkitt lymphoma receptor 1,CXC-R5,Gpcr6,BLR1 |
| Background | Antibody anti-CXCR5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CXCR5 is a G protein-coupled receptor expressed mainly on follicular B cells and T follicular helper (Tfh) cells, where it binds its ligand CXCL13. CXCR5 is critical for B cell homing to lymphoid follicles within secondary lymphoid organs, such as lymph nodes, spleen, and Peyer’s patches. It guides the migration of B cells and Tfh cells to germinal centers, facilitating antibody production, affinity maturation, and immune memory formation. CXCR5 signaling activates pathways like PI3K and ERK, driving cell migration and positioning within lymphoid tissues. In autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, dysregulated CXCR5 expression contributes to abnormal germinal center formation and autoantibody production. CXCR5 is also involved in chronic inflammatory diseases where it promotes immune cell accumulation. In cancer, CXCR5 expression is observed in B cell lymphomas and some solid tumors, where it enhances tumor growth, immune evasion, and metastasis. CXCL13-CXCR5 signaling in the tumor microenvironment supports lymphoid tissue-like structures that promote tumor progression. Therapeutically, targeting CXCR5 is being explored to modulate B cell activity in autoimmune diseases and lymphomas. CXCR5 is essential for coordinating B and Tfh cell migration, ensuring proper immune responses while contributing to disease pathology when dysregulated.
Productos relacionados
Chemokine C-X-C-Motif Receptor 5 (CXCR5) Antibody
This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encod…
Ver producto
Human Chemokine C-X-C-Motif Receptor 5 (CXCR5) ELISA Kit
Human Chemokine C-X-C-Motif Receptor 5 (CXCR5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Hu…
Ver producto Chemokine C-X-C-Motif Receptor 5 (CXCR5) Antibody
CXCR5 Antibody is a Rabbit Polyclonal against CXCR5.…
Ver producto