Human Chemokine C-X-C-Motif Receptor 5 (CXCR5) CLIA Kit

Este producto es parte de CXCR - C-X-C motif chemokine receptor
Human Chemokine C-X-C-Motif Receptor 5 (CXCR5) CLIA Kit
845€ (96 tests)

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Name
Human Chemokine C-X-C-Motif Receptor 5 (CXCR5) CLIA Kit
Category
CLIA Kits
Provider
Abbexa
Reference
abx492223
Tested Applications
CLIA

Description

Human CXCR5 Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
CLIA Kits
Immunogen Target
Chemokine C-X-C-Motif Receptor 5 (CXCR5)
Reactivity
Human
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.055 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard: Lyophilized
Tested Applications
CLIA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-20 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
CXCR5,BLR-1,MDR15,NLR,CD185,Burkitt lymphoma receptor 1,CXC-R5,Gpcr6,BLR1
Background
CLIA Kits CXCR5
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES.  The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.  Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

CXCR5 is a G protein-coupled receptor expressed mainly on follicular B cells and T follicular helper (Tfh) cells, where it binds its ligand CXCL13. CXCR5 is critical for B cell homing to lymphoid follicles within secondary lymphoid organs, such as lymph nodes, spleen, and Peyer’s patches. It guides the migration of B cells and Tfh cells to germinal centers, facilitating antibody production, affinity maturation, and immune memory formation. CXCR5 signaling activates pathways like PI3K and ERK, driving cell migration and positioning within lymphoid tissues. In autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, dysregulated CXCR5 expression contributes to abnormal germinal center formation and autoantibody production. CXCR5 is also involved in chronic inflammatory diseases where it promotes immune cell accumulation. In cancer, CXCR5 expression is observed in B cell lymphomas and some solid tumors, where it enhances tumor growth, immune evasion, and metastasis. CXCL13-CXCR5 signaling in the tumor microenvironment supports lymphoid tissue-like structures that promote tumor progression. Therapeutically, targeting CXCR5 is being explored to modulate B cell activity in autoimmune diseases and lymphomas. CXCR5 is essential for coordinating B and Tfh cell migration, ensuring proper immune responses while contributing to disease pathology when dysregulated.

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