Human BTB/POZ domain-containing protein KCTD8 (KCTD8) ELISA Kit

Product specifications

ELISA Kits

BTB/POZ domain-containing protein KCTD8 (KCTD8)

Human

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q6ZWB6

618442

KCTD8,BTB/POZ domain-containing protein KCTD8,

Elisa kits for KCTD8

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

KCTD8 is a member of the potassium channel tetramerization domain (KCTD) family, known for its role as an auxiliary subunit of GABA-B receptors. It modulates the pharmacology and kinetics of GABA-B receptor signaling, influencing inhibitory neurotransmission in the central nervous system. KCTD8 binds to the GABA-B receptor complex, regulating receptor activation, desensitization, and downstream signaling pathways mediated by Gi/o proteins. It is primarily expressed in brain regions involved in cognition, motor control, and emotional regulation, contributing to synaptic plasticity and neuronal excitability. KCTD8 has also been implicated in mood disorders, such as anxiety and depression, where dysregulation of GABA-B signaling disrupts inhibitory balance. Beyond neurotransmission, KCTD8 participates in protein-protein interactions through its BTB/POZ domain, regulating cellular processes like ubiquitination and transcriptional repression. Altered expression of KCTD8 has been associated with neurological disorders and certain cancers. Its function as a GABA-B receptor modulator positions KCTD8 as a target of interest for improving treatments for neurological and psychiatric conditions.

Related Products

BTB/POZ Domain-Containing Protein KCTD8 (KCTD8) Antibody

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

Ver Producto

BTB/POZ Domain-Containing Protein KCTD8 (KCTD8) Antibody

Rabbit Polyclonal against the KCTD8 protein.

Ver Producto

Human BTB/POZ domain-containing protein KCTD8 (KCTD8) ELISA Kit

Human BTB/POZ domain-containing protein KCTD8 (KCTD8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human BTB/POZ domain-containing protein KCTD8 (KCTD8) concentrations in tissue homogenates, cell lysates and other biological fluids.

Ver Producto