BTB/POZ Domain-Containing Protein KCTD8 (KCTD8) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
BTB/POZ Domain-Containing Protein KCTD8 (KCTD8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026347
tested applications
ELISA, WB, IHC
Description
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | BTB/POZ Domain-Containing Protein KCTD8 (KCTD8) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ZWB6 |
| Alias | KCTD8,BTB/POZ domain-containing protein KCTD8, |
| Background | Antibody anti-KCTD8 |
| Status | RUO |
Descripción
KCTD8 is a member of the potassium channel tetramerization domain (KCTD) family, known for its role as an auxiliary subunit of GABA-B receptors. It modulates the pharmacology and kinetics of GABA-B receptor signaling, influencing inhibitory neurotransmission in the central nervous system. KCTD8 binds to the GABA-B receptor complex, regulating receptor activation, desensitization, and downstream signaling pathways mediated by Gi/o proteins. It is primarily expressed in brain regions involved in cognition, motor control, and emotional regulation, contributing to synaptic plasticity and neuronal excitability. KCTD8 has also been implicated in mood disorders, such as anxiety and depression, where dysregulation of GABA-B signaling disrupts inhibitory balance. Beyond neurotransmission, KCTD8 participates in protein-protein interactions through its BTB/POZ domain, regulating cellular processes like ubiquitination and transcriptional repression. Altered expression of KCTD8 has been associated with neurological disorders and certain cancers. Its function as a GABA-B receptor modulator positions KCTD8 as a target of interest for improving treatments for neurological and psychiatric conditions.
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