Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (GCNT4) ELISA Kit
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935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits GCNT4
proveedor
Abbexareference
abx525010Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (GCNT4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (GCNT4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Glucosaminyl (N-acetyl) transferase 4 (GCNT4) is a glycosyltransferase enzyme responsible for catalyzing the formation of core 2 O-glycans, critical components of glycoproteins and mucins involved in cellular adhesion, signaling, and epithelial protection GCNT4 is expressed primarily in the gastrointestinal tract, pancreas, and other mucin-secreting tissues where it contributes to the maintenance of epithelial integrity and mucus production Studies have shown that GCNT4 plays a role in regulating glycoprotein branching, which is essential for cell surface interactions and immune responses Dysregulation of GCNT4 has been linked to colorectal and pancreatic cancers, where altered glycosylation promotes tumor growth, metastasis, and resistance to apoptosis Furthermore, GCNT4 expression is modulated during inflammatory conditions, impacting mucosal defense and contributing to diseases like ulcerative colitis and Crohn’s disease Emerging evidence highlights its role in epithelial homeostasis and its potential as a biomarker for gastrointestinal diseases and therapeutic target for cancer treatment
Características del producto
category
ELISA Kits
immunogen target
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (GCNT4)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
Core 2-branching enzyme 3,Core2-GlcNAc-transferase 3,C2GnT3,LINC01338
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
GCNT4
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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