Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 4 (GCNT4) Antibody

Este producto es parte de GCNT - glucosaminyl (N-acetyl) transferase
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351€ (100 µg)

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935106861
info@markelab.com
name
Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 4 (GCNT4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx375489
tested applications
ELISA, WB

Description

Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 4 (GCNT4) Antibody is a Rabbit Polyclonal antibody against Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 4 (GCNT4).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 4 (GCNT4)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified by affinity chromatography using epitope-specific immunogen.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9P109
Gene ID
51301
Alias
Core 2-branching enzyme 3,Core2-GlcNAc-transferase 3,C2GnT3,LINC01337
Background
Antibody anti-GCNT4
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

Glucosaminyl (N-acetyl) transferase 4 (GCNT4) is a glycosyltransferase enzyme responsible for catalyzing the formation of core 2 O-glycans, critical components of glycoproteins and mucins involved in cellular adhesion, signaling, and epithelial protection GCNT4 is expressed primarily in the gastrointestinal tract, pancreas, and other mucin-secreting tissues where it contributes to the maintenance of epithelial integrity and mucus production Studies have shown that GCNT4 plays a role in regulating glycoprotein branching, which is essential for cell surface interactions and immune responses Dysregulation of GCNT4 has been linked to colorectal and pancreatic cancers, where altered glycosylation promotes tumor growth, metastasis, and resistance to apoptosis Furthermore, GCNT4 expression is modulated during inflammatory conditions, impacting mucosal defense and contributing to diseases like ulcerative colitis and Crohn’s disease Emerging evidence highlights its role in epithelial homeostasis and its potential as a biomarker for gastrointestinal diseases and therapeutic target for cancer treatment

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