Human B-Cell Linker Protein (BLNK) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for BLNK
proveedor
Abbexareference
abx354317Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human B-Cell Linker Protein (BLNK) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human B-Cell Linker Protein concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
BLNK (B-cell linker) is an adaptor protein primarily expressed in B cells, where it plays a crucial role in regulating B cell receptor (BCR) signaling. It functions by linking various signaling molecules, which is critical for the proper activation, differentiation, and survival of B cells. Upon BCR engagement, BLNK is phosphorylated, leading to the recruitment of other signaling proteins, including those involved in the activation of key pathways such as the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. This allows BLNK to help orchestrate B cell activation and the immune response. It is also involved in regulating B cell proliferation and the transition from the naive to the activated state, essential for effective immune responses. Mutations in BLNK can result in immune dysfunction and are associated with immune-related diseases, including lymphoid malignancies. Understanding its role in B cell signaling can help inform therapies for diseases involving B cells, such as autoimmune diseases and B-cell malignancies.
Características del producto
category
ELISA Kits
immunogen target
B-Cell Linker Protein (BLNK)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
0.1 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
BLNK, AGM4, BASH, BLNK-S, LY57,B-cell adapter containing a SH2 domain protein,Cytoplasmic adapter protein
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
BLNK
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Quizá le pueda interesar
anti- BLNK antibody
proveedor
FineTestreference
FNab00908Tested Applications
ELISA, WB, IHCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalFunctions as a central linker protein, downstream of the B-cell receptor(BCR), bridging the SYK kinase to a multitude of...
Precio a consultar
Ver másRecombinant Human BLNK
proveedor
FineTestreference
P6276Tested Applications
Western Blot，ELISAstatus
RUOPrecio a consultar
Ver másB-Cell Linker Protein (BLNK) Antibody
proveedor
Abbexareference
abx011968Tested Applications
ELISA, WB, IHC, IF/ICC, FCMreactivity
Human, Mousestatus
RUOclonality
MonoclonalThis gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein...
383.5€ (100 µl)
Ver más