B-Cell Linker Protein (BLNK) Antibody
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Description
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | B-Cell Linker Protein (BLNK) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WV28 |
| Gene ID | 29760 |
| Alias | BLNK, AGM4, BASH, BLNK-S, LY57,B-cell adapter containing a SH2 domain protein,Cytoplasmic adapter protein |
| Background | Antibody anti-BLNK |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
BLNK (B-cell linker) is an adaptor protein primarily expressed in B cells, where it plays a crucial role in regulating B cell receptor (BCR) signaling. It functions by linking various signaling molecules, which is critical for the proper activation, differentiation, and survival of B cells. Upon BCR engagement, BLNK is phosphorylated, leading to the recruitment of other signaling proteins, including those involved in the activation of key pathways such as the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. This allows BLNK to help orchestrate B cell activation and the immune response. It is also involved in regulating B cell proliferation and the transition from the naive to the activated state, essential for effective immune responses. Mutations in BLNK can result in immune dysfunction and are associated with immune-related diseases, including lymphoid malignancies. Understanding its role in B cell signaling can help inform therapies for diseases involving B cells, such as autoimmune diseases and B-cell malignancies.
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