This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This antibody is supplied as crude ascites.
Primary Antibodies
Monoclonal
Human
B-Cell Linker Protein (BLNK)
Mouse
Unconjugated
Liquid
ELISA, WB
Unpurified crude ascites.
Ascites containing 0.09% sodium azide.
100 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
BLNK
No
Shipped within 5-10 working days.
BLNK, AGM4, BASH, BLNK-S, LY57,B-cell adapter containing a SH2 domain protein,Cytoplasmic adapter protein
This product is for research use only.
Functions as a central linker protein, downstream of the B-cell receptor(BCR), bridging the SYK kinase to a multitude of...
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Ver másThis gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein...
362.5€ (100 µl)
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