Human Annexin A3 (ANXA3) Protein
234€ (10 µg)
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935106861
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name
Human Annexin A3 (ANXA3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065369
tested applications
WB, SDS-PAGE
Description
Recombinant Annexin A3 (ANXA3) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Annexin A3 (ANXA3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 15.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Trp190-Glu312 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P12429 |
| Alias | ANXA3,ANX3,Annexin-3,Lipocortin III |
| Background | Protein ANXA3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ANXA3 is a calcium- and phospholipid-binding protein that regulates membrane trafficking, signal transduction, and inflammatory responses. It is expressed in various tissues, including immune and endothelial cells, and plays a role in angiogenesis and immune cell function. ANXA3 regulates phospholipase A2 (PLA2) activity, influencing arachidonic acid metabolism and eicosanoid production during inflammation. Dysregulation of ANXA3 has been associated with drug resistance in cancer cells, particularly in ovarian and colorectal cancers, where it enhances tumor cell survival and chemoresistance. Its involvement in immune responses and tumor progression underscores its significance as a potential biomarker and therapeutic target.
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Annexin A3(Anxa3), also named as lipocortin3, placental anticoagulant protein3(PAP-III), belongs to annexin family. Annexins are calcium-dependent phospholipids-binding high-abundant intracellular proteins. ANXA3 has been reported to play crucial roles in a diverse range of molecular and cellular processes, including ion channel regulation, anticoagulation, anti-inflammation, vesicle traffick-ing, signal transduction, cell migration, and cell proliferation. It also exhibits important roles in cancer progression, metastasis, and drug resistance.
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