Name: anti- Annexin A3 antibody
Brand: FineTest
SKU: FNab00433
Availability: OnlineOnly

Descripción

Annexin A3(Anxa3), also named as lipocortin3, placental anticoagulant protein3(PAP-III), belongs to annexin family. Annexins are calcium-dependent phospholipids-binding high-abundant intracellular proteins. ANXA3 has been reported to play crucial roles in a diverse range of molecular and cellular processes, including ion channel regulation, anticoagulation, anti-inflammation, vesicle traffick-ing, signal transduction, cell migration, and cell proliferation. It also exhibits important roles in cancer progression, metastasis, and drug resistance.

Background

ANXA3 is a calcium- and phospholipid-binding protein that regulates membrane trafficking, signal transduction, and inflammatory responses. It is expressed in various tissues, including immune and endothelial cells, and plays a role in angiogenesis and immune cell function. ANXA3 regulates phospholipase A2 (PLA2) activity, influencing arachidonic acid metabolism and eicosanoid production during inflammation. Dysregulation of ANXA3 has been associated with drug resistance in cancer cells, particularly in ovarian and colorectal cancers, where it enhances tumor cell survival and chemoresistance. Its involvement in immune responses and tumor progression underscores its significance as a potential biomarker and therapeutic target.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

annexin A3

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC, IP

observerd MW

36 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:2000; IHC: 1:20-1:200; IP:1:200-1:2000

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

ANXA3

alias

ANXA3,ANX3,Annexin-3,Lipocortin III

uniprot id

https://www.uniprot.org/uniprotkb/P12429

note

This product is for research use only.

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Human ANXA3(Annexin A3) ELISA Kit

proveedor

FineTest

reference

EH0854

reactivity

human

status

RUO

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