Human Aminoadipate Aminotransferase (AADAT) Protein

Este producto es parte de AADAT - Aminoadipate Aminotransferase
Human Aminoadipate Aminotransferase (AADAT) Protein

Pida mas información

935106861

info@markelab.com

Precio

208€ (10 µg)

Protein AADAT

proveedor

Abbexa

reference

abx650511

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human AADAT Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Aminoadipate aminotransferase (AADAT), also known as kynurenine aminotransferase II (KAT II), is a mitochondrial enzyme that catalyzes the transamination of kynurenine to kynurenic acid (KYNA), a neuroactive metabolite in the kynurenine pathway of tryptophan metabolism. KYNA acts as an antagonist of NMDA and alpha-7 nicotinic acetylcholine receptors, regulating excitotoxicity and neuroinflammation in the brain. AADAT is expressed in various tissues, with high activity in the brain, where it influences neurotransmission and neuroprotection. Dysregulation of AADAT or kynurenine pathway metabolites has been linked to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and schizophrenia, as well as cancer and immune-related disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Aminoadipate Aminotransferase (AADAT)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 29.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn202-Ser425 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

AADAT


dry ice

No


availability

Shipped within 5-7 working days.


alias

KAT2,KATII,KYAT2,Kynurenine Aminotransferase II


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reactivity

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clonality

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