Aminoadipate Aminotransferase (AADAT) Antibody
286€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Aminoadipate Aminotransferase (AADAT) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx131228
Tested Applications
WB, IHC
Description
Aminoadipate Aminotransferase Antibody is a Rabbit Polyclonal against Aminoadipate Aminotransferase.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aminoadipate Aminotransferase (AADAT) Immunogen: AADAT (Thr99-Leu425) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | KAT2,KATII,KYAT2,Kynurenine Aminotransferase II |
| Background | Antibody anti-AADAT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Aminoadipate aminotransferase (AADAT), also known as kynurenine aminotransferase II (KAT II), is a mitochondrial enzyme that catalyzes the transamination of kynurenine to kynurenic acid (KYNA), a neuroactive metabolite in the kynurenine pathway of tryptophan metabolism. KYNA acts as an antagonist of NMDA and alpha-7 nicotinic acetylcholine receptors, regulating excitotoxicity and neuroinflammation in the brain. AADAT is expressed in various tissues, with high activity in the brain, where it influences neurotransmission and neuroprotection. Dysregulation of AADAT or kynurenine pathway metabolites has been linked to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and schizophrenia, as well as cancer and immune-related disorders.
Productos relacionados
Aminoadipate Aminotransferase (AADAT) Antibody
Aminoadipate Aminotransferase Antibody is a Rabbit Polyclonal antibody against Aminoadipate Aminotransferase.…
Ver producto Aminoadipate Aminotransferase (AADAT) Antibody
Rabbit Polyclonal against the AADAT protein.…
Ver producto Aminoadipate Aminotransferase (AADAT) Antibody
Aminoadipate Aminotransferase Antibody is a Rabbit Polyclonal against Aminoadipate Aminotransferase.…
Ver producto