Aminoadipate Aminotransferase (AADAT) Antibody

Este producto es parte de AADAT - Aminoadipate Aminotransferase
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286€ (100 µl)

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935106861
info@markelab.com
name
Aminoadipate Aminotransferase (AADAT) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131228
tested applications
WB, IHC, IF/ICC

Description

Aminoadipate Aminotransferase Antibody is a Rabbit Polyclonal against Aminoadipate Aminotransferase.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Aminoadipate Aminotransferase (AADAT)
Host
Rabbit
Reactivity
Mouse
Recommended Dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Size 1
100 µl
Size 2
200 µl
Size 3
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-7 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
KAT2,KATII,KYAT2,Kynurenine Aminotransferase II
Background
Antibody anti-AADAT
Status
RUO

Descripción

Aminoadipate aminotransferase (AADAT), also known as kynurenine aminotransferase II (KAT II), is a mitochondrial enzyme that catalyzes the transamination of kynurenine to kynurenic acid (KYNA), a neuroactive metabolite in the kynurenine pathway of tryptophan metabolism. KYNA acts as an antagonist of NMDA and alpha-7 nicotinic acetylcholine receptors, regulating excitotoxicity and neuroinflammation in the brain. AADAT is expressed in various tissues, with high activity in the brain, where it influences neurotransmission and neuroprotection. Dysregulation of AADAT or kynurenine pathway metabolites has been linked to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and schizophrenia, as well as cancer and immune-related disorders.

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