Aminoadipate Aminotransferase (AADAT) Antibody
637€ (100 µl)
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935106861
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name
Aminoadipate Aminotransferase (AADAT) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx110948
tested applications
ELISA, IHC
Description
Aminoadipate Aminotransferase Antibody is a Rabbit Polyclonal antibody against Aminoadipate Aminotransferase.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aminoadipate Aminotransferase (AADAT) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N5Z0 |
| Gene ID | 51166 |
| NCBI Accession | NP_001273611.1, NM_001286682.1, NP_001273612.1, NM_001286683.1 |
| OMIM | 611754 |
| Alias | KAT2,KATII,KYAT2,Kynurenine Aminotransferase II |
| Background | Antibody anti-AADAT |
| Status | RUO |
Descripción
Aminoadipate aminotransferase (AADAT), also known as kynurenine aminotransferase II (KAT II), is a mitochondrial enzyme that catalyzes the transamination of kynurenine to kynurenic acid (KYNA), a neuroactive metabolite in the kynurenine pathway of tryptophan metabolism. KYNA acts as an antagonist of NMDA and alpha-7 nicotinic acetylcholine receptors, regulating excitotoxicity and neuroinflammation in the brain. AADAT is expressed in various tissues, with high activity in the brain, where it influences neurotransmission and neuroprotection. Dysregulation of AADAT or kynurenine pathway metabolites has been linked to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and schizophrenia, as well as cancer and immune-related disorders.
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