Human Adenylate Cyclase 1, Brain (ADCY1) Protein
234€ (10 µg)
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935106861
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name
Human Adenylate Cyclase 1, Brain (ADCY1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166977
tested applications
WB, SDS-PAGE
Description
Adenylate Cyclase 1, Brain Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Adenylate Cyclase 1, Brain (ADCY1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 29.3 kDa Observed MW (SDS-PAGE): 29 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg835-Asn1061 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AC1,DFNB44,ATP pyrophosphate-lyase 1 |
| Background | Protein ADCY1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADCY1 is a membrane-bound enzyme predominantly expressed in the brain, specifically in neuronal tissues. It is activated by G-protein-coupled receptors (GPCRs) and regulated by calcium/calmodulin, playing a vital role in generating cyclic AMP (cAMP), a second messenger critical for signal transduction. ADCY1 is essential for synaptic plasticity, learning, and memory processes. Dysregulation of ADCY1 has been linked to neurological disorders, such as cognitive impairments and epilepsy, due to impaired cAMP signaling pathways. Its expression and activity are crucial for calcium-dependent cAMP production in neurons.
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