Human ACAT1 (Acetyl-CoA acetyltransferase, mitochondrial) ELISA Kit

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935106861
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name
Human ACAT1 (Acetyl-CoA acetyltransferase, mitochondrial) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH0798
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | ELISA Kits |
Reactivity | Human |
Detection Method | Colorimetric |
Assay Data | 4 hours |
Assay Type | Sandwich ELISA, Double Antibody |
Test Range | 7.813-500pg/ml |
Sensitivity | 4.688pg/ml |
Size 1 | 96T |
Tested Applications | ELISA |
Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
Availability | Shipped within 10-14 working days. |
Storage | 2-8 °C for 12 months |
UniProt ID | P24752 |
Alias | ACAT,MAT,T2,THIL,Acetoacetyl-CoA thiolase |
Background | Elisa kits for ACAT1 |
Status | RUO |
ACAT1, also known as mitochondrial acetoacetyl-CoA thiolase, is an enzyme localized in the mitochondria that catalyzes the reversible conversion of two molecules of acetyl-CoA into acetoacetyl-CoA, a critical step in ketone body synthesis and cholesterol metabolism. It is involved in energy production during periods of fasting or carbohydrate restriction by contributing to ketogenesis. ACAT1 also plays a role in the breakdown of branched-chain amino acids, linking it to amino acid metabolism. Dysregulation or mutations in the ACAT1 gene have been implicated in rare metabolic disorders such as beta-ketothiolase deficiency, which is characterized by the inability to properly metabolize ketogenic amino acids and fatty acids, leading to metabolic acidosis. Recent studies have also suggested a potential role for ACAT1 in cancer metabolism, where its activity is linked to metabolic reprogramming in tumor cells.
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This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
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