ACAT1 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
ACAT1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00072
Tested Applications
ELISA, WB, IHC
Description
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | acetyl-Coenzyme A acetyltransferase 1 (ACAT1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 40 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P24752 |
| Gene ID | 38 |
| Alias | ACAT,MAT,T2,THIL,Acetoacetyl-CoA thiolase |
| Background | Antibody anti-ACAT1 |
| Status | RUO |
| Note | Mol. Weight 40 kDa |
Background
ACAT1, also known as mitochondrial acetoacetyl-CoA thiolase, is an enzyme localized in the mitochondria that catalyzes the reversible conversion of two molecules of acetyl-CoA into acetoacetyl-CoA, a critical step in ketone body synthesis and cholesterol metabolism. It is involved in energy production during periods of fasting or carbohydrate restriction by contributing to ketogenesis. ACAT1 also plays a role in the breakdown of branched-chain amino acids, linking it to amino acid metabolism. Dysregulation or mutations in the ACAT1 gene have been implicated in rare metabolic disorders such as beta-ketothiolase deficiency, which is characterized by the inability to properly metabolize ketogenic amino acids and fatty acids, leading to metabolic acidosis. Recent studies have also suggested a potential role for ACAT1 in cancer metabolism, where its activity is linked to metabolic reprogramming in tumor cells.
Productos relacionados
Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody
ACAT1 Antibody is a Rabbit Polyclonal antibody against ACAT1. This gene encodes a mitochondrially localized enzyme that …
Ver producto
Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody
ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecule…
Ver producto
Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody
Rabbit Polyclonal against the ACAT1 protein.…
Ver producto