ACAT1 antibody

Este producto es parte de ACAT - Acetyl Coenzyme A Acetyltransferase
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935106861
info@markelab.com
name
ACAT1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00072
tested applications
ELISA, WB, IHC

Description

This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
acetyl-Coenzyme A acetyltransferase 1 (ACAT1)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
40 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
UniProt ID
P24752
Gene ID
38
Alias
ACAT,MAT,T2,THIL,Acetoacetyl-CoA thiolase
Background
Antibody anti-ACAT1
Status
RUO
Note
Mol. Weight 40 kDa

Descripción

ACAT1, also known as mitochondrial acetoacetyl-CoA thiolase, is an enzyme localized in the mitochondria that catalyzes the reversible conversion of two molecules of acetyl-CoA into acetoacetyl-CoA, a critical step in ketone body synthesis and cholesterol metabolism. It is involved in energy production during periods of fasting or carbohydrate restriction by contributing to ketogenesis. ACAT1 also plays a role in the breakdown of branched-chain amino acids, linking it to amino acid metabolism. Dysregulation or mutations in the ACAT1 gene have been implicated in rare metabolic disorders such as beta-ketothiolase deficiency, which is characterized by the inability to properly metabolize ketogenic amino acids and fatty acids, leading to metabolic acidosis. Recent studies have also suggested a potential role for ACAT1 in cancer metabolism, where its activity is linked to metabolic reprogramming in tumor cells.

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