Human A-kinase anchor protein 6 (AKAP6) ELISA Kit
715€ (96 tests)
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935106861
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name
Human A-kinase anchor protein 6 (AKAP6) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501413
tested applications
ELISA
Description
Human A-kinase anchor protein 6 (AKAP6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human A-kinase anchor protein 6 (AKAP6) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | A-kinase anchor protein 6 (AKAP6) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q13023 |
| Gene ID | 9472 |
| OMIM | 604691 |
| Alias | AKAP6, AKAP100, KIAA0311 |
| Background | Elisa kits for AKAP6 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP6, also known as mAKAP (muscle AKAP), is a scaffold protein predominantly expressed in cardiac and skeletal muscle cells. It anchors PKA and other signaling molecules, such as phosphodiesterases (PDEs) and calcium-handling proteins, to the nuclear envelope, creating a signaling hub that regulates hypertrophic responses, calcium dynamics, and transcription. AKAP6 is critical for cardiomyocyte function, as it spatially coordinates cAMP signaling and calcium release to control excitation-contraction coupling and cardiac remodeling under stress. It interacts with PDE4D to regulate local cAMP levels and prevent hyperactivation of PKA, ensuring precise signaling. Mutations or dysfunctions in AKAP6 are associated with pathological cardiac hypertrophy and heart failure. Additionally, AKAP6 integrates signals from beta-adrenergic receptors, impacting gene transcription through interactions with nuclear factor NFAT and histone deacetylases. AKAP6’s unique role in organizing nuclear and perinuclear signaling makes it vital for cardiac development and adaptive responses to physiological stress.
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